Optimization of Electrocoagulation via Response Surface Methodology to Remove Ciprofloxacin from Aqueous Media

Document Type : Research Paper


1 Assoc. Prof. of Environmental Health, Faculty of Public Health, Hamadan University of Medical Sciences, Hamadan, Iran

2 MSc Student of Environmental Health Engineering, Hamadan Universty of Medical Sciences, Hamadan, Iran

3 Former Graduate Student of Environmental Health, Student Research Committee on Environmental Health Engineering, Hamadan University of Medical Sciences, Hamadan, Iran

4 PhD Student of Chemistry, Faculty of Chemistry and Chemical Engineering, Tehran Branch, Malek-E-Ashtar University

5 MSc Student of Chemistry, Imam Khomeini International University, Ghazvin, Iran

6 BS Student of Environmental Health, Student Research Committee on Environmental Health Engineering, Hamadan University of Medical Sciences, Hamadan, Iran

7 Former Graduate Student of Environmental Health, Student Research Committee on Environmental Health Engineering, Hamadan University of Meical Sciences, Hamadan, Iran


The response surface statistical model developed via the central composite design (CCD) is a tool for optimizing manufacturing processes. Phrmaceutical plants depend on many such processes and i is essential to remove medicinal compounds from their effluents before they are discharged into the environment. The objective of the present study was to employ the response surface model for the optimization of the removal of the pharmaceutical compound ciprofloxacin from aqueous media via the electrochemical coagulation process. In this study, a reactor containing two iron electrodes used as the anode and two titanium ones used as the cathode was employed to remove ciprofloxacin from municipal effluents. The electrodes were connected in a monopolar fashion to a DC power supply. Parameters such as pH (4‒8), current (0.5‒1.5 A), initial ciprofloxacin concentration (15‒40 mg/L), and reaction time (15‒30 min) were introduced into the Design Expert software as the main design parameters. FT-IR analysis was conducted and SEM images were prepared while COD removal and changes in UV-VIS spectrum were determined under optimum conditions. Process modeling was accomplished using the response surface methodology (RSM) which is a statistical model for process optimization drawing upon central composite design (CCD). Modeling results showed that process efficiency was affected by the above parameters and that the optimum conditions for a process efficiency of 85.91% at an initial CIP concentration of 15mg/L would include pH=7.68, a current of 1.5 A, and a reaction time of 30 min. Under these conditions, COD removal efficiency would be 64%. FT-IR analysis and SEM images indicated changes during the process. Wavelength scanning also indicated reducing concentration of the contaminant due to mineralization. The results of the study indicate that optimization by RSM reduces the number of tests required and enhances their accuracy. It was also found that electrocoagulation has a high CIP and COD removal efficiency which makes it capable of being successfully exploited for the removal of organic pollutants from effluents before their discharge into the environment


Main Subjects

Abu Hasan, H., Rozaimah Sheikh Abdullah, S., Kartom Kamarudin, S. & Tan Kofli, N., 2011, "Response surface methodology for optimization of simultaneous COD, NH4+–N and Mn2+ removal from drinking water by biological aerated filter", Desalination, 275(1), 50-61.
Ahmed, M.G., Harish, N.M., Charyulu, R.N. & Prabhu, P., 2009, "Formulation of chitosan-based ciprofloxacin and diclofenac film for periodontitis therapy", Tropical Journal of Pharamaceutical, 8(1), 33-41.
Aoudj, S., Khelifa, A., Drouiche, N., Hecini, M. & Hamitouche, H., 2010, "Electrocoagulation process applied to wastewater containing dyes from textile industry", Chemical Engineering Research Design, 49(11), 1176-1182.
APHA., AWWA., WEF., 2012, Standard methods for the examination of water and wastewater, 22nd Ed., USA.
Can, O., 2014, "COD removal from fruit-juice production wastewater by electrooxidation electrocoagulation and electro-Fenton processes", Desalination Water Treatment, 52(1-3), 65-73.
Carabineiro, S., Thavorn-Amornsri, T., Pereira, M. & Figueiredo, J., 2011, "Adsorption of ciprofloxacin on surface-modified carbonmaterials", Water Research, 45, 4583-4591.
Choi, K.J., Kim, S.G. & Kim, S.H., 2008, "Removal of antibiotics by coagulation and granular activated carbon filtration", J. Hazardous Materials, 151(1), 38-43.
Choi, K.J., Son, H.J. & Kim, SH., 2007, "Ionic treatment for removal of sulfonamide and tetracycline classes of antibiotic", Science Total Environmental, 387(1), 247-256.
Crisafully, R., Aparecida, M., Cavalcante, R.M., Silveira, E.R., Keukeleire, D.D. & Nascimento, R.F., 2008. "Removal of some polycyclic aromatic hydrocarbons from petrochemical wastewater using low-cost adsorbents of natural origin.” Bioresource Technology, 99(10), 4515-4519.
Daneshvar, N., Oladegaragoze, A., and Djafarzadeh, N., 2006, "Decolorization of basic dye solutions by electrocoagulation: An investigation of the effect of operational parameters", Journal Hazardous Materials, 129(1), 116-22.
Dimitrakopoulou, D., Rethemiotaki, I., Frontistis, Z., Xekoukoulotakis, N., Venieri, D. & Mantzavinos, D., 2012, "Degradation, mineralization and antibiotic inactivation of amoxicillin by UV-A/TiO2 photocatalysis", Journal Environmenal Management, 98,168-170.
Farhadi, S., Aminzadeh, B., Torabian, A., Khatibikamal, V. & Alizadeh Fard, M., 2012, "Comparison of COD removal from pharmaceutical wastewater by electrocoagulation, photoelectrocoagulation, peroxi-electrocoagulation and peroxi-photoelectrocoagulation processes", Journal Hazardous Materials, 219, 35-42.
Garcia-Garcia, A., Martinez-Miranda, V., Ivan, G., Cienfuegos, M., Tatiana, P., Sanchez, A., et al., 2014, "Industrial wastewater treatment by electrocoagulation–electrooxidation processes powered by solar cells", Fuel, 149, 46-54.
آب و فاضلاب                                                                                                                    شماره 2 سال 1396
Guinea, E., Brillas, E., Centellas, F., Canizares, P., Rodrigo, M. & Saez, C., 2009, "Oxidation of enrofloxacin with conductive-diamond electrochemical oxidation, ozonation and fenton oxidation", Water Reserach, 43(8), 2131-2138.
Hernando, M.D., Mezcua, M., Fernández-Alba, A.R. & Barcelo, D., 2006, "Environmental risk assessment of pharmaceutical residues in wastewater effluents, surface waters and sediments", Talanta, 69(2), 334-342.
Imran, A., Vinod, K., Tabrez, A. & Asim, M., 2012, "Removal of arsenate from aqueous solution by electro-coagulation method using Al-Fe electrodes", International Journal Electrochemical Sciences, 7, 1898-1907.
Kobya, M., Demirbas, E., Can, O.T. & Bayramoglu, M., 2006, "Treatment of levafix orange textile dye solution by electrocoagulation", Journal Hazardous Materials, 132(2),183-188.
Ölmez, T., 2009, "The optimization of Cr(VI) reduction and removal by electrocoagulation using response surface methodology", Journal Hazardous Materials, 162,1371-1378.
Rozas, O., Contreras, D., Mondaca, M., Pérez-Moya, M. & Héctor, D., 2010, "Experimental design of fenton and photo-fenton reactions for the treatment of ampicillin solutions", Journal Hazardous Materials, 177(1), 1025-1030.
Şengil, İ.A. & Özacar, M., 2009, "The decolorization of CI Reactive Black 5 in aqueous solution by electrocoagulation using sacrificial iron electrodes", Journal Hazardous Materials, 161(2), 1369-1376.
Shannag, M., Al-Qodah, Z., Bani-Melhem, Kh., Rasool Qtaishat, M. & Alkasrawi, M., 2014, "Heavy metal ions removal from metal plating wastewater using electrocoagulation: Kinetic study and process performance", Chemical Engineering Journal,260, 749-756.
Xu, H., Yang, Zh., Zeng, G, Luo, Y., Huang, J., Wang, Li., Song, P. & Mo, X., 2014, "Investigation of pH evolution with Cr (VI) removal in electrocoagulation process: Proposing a real-time control strategy", Chemical Enginering Journal, 239, 132-140.
Zeng, Z., Zou, H., Li, X., Sun, B., Chen, J. & Shao, L., 2012, "Ozonation of acidic phenol wastewater with O3/Fe (II) in a rotating packed bed reactor: Optimization by response surface methodology", Chemical Engineering Research and Design, 60, 1-8.
Zhang, X., Zhang, Y., Zhao, H., He, Y., Li, X. & Yuan, Zh., 2013, "Highly sensitive and selective colorimetric sensing of antibiotics in milk", Analitical Chemical Acta, 778, 63-69.