کارایی فرایند ازن‌زنی‌کاتالیزوری با نانوذرات اکسیدمنیزیم در حذف آنتی بیوتیک سفتریاکسون از محیط‌های آبی

نوع مقاله : مقاله پژوهشی

نویسندگان

1 دانشجوی کارشناسی ارشد بهداشت محیط، گروه مهندسی بهداشت محیط، دانشکده بهداشت، دانشگاه علوم پزشکی ایران، تهران، ایران

2 استاد،گروه مهندسی بهداشت محیط،دانشکده بهداشت ،دانشگاه علوم پزشکی ایران ،تهران ، ایران

3 استادیار ، گروه مهندسی بهداشت محیط، دانشکده بهداشت، دانشگاه علوم پزشکی ایران، تهران، ایران

4 دانشیار ، گروه مهندسی بهداشت محیط، دانشکده بهداشت، دانشگاه علوم پزشکی ایران، تهران، ایران

5 استادیار، گروه مهندسی بهداشت محیط، دانشکده بهداشت، دانشگاه علوم پزشکی گرگان، گرگان، ایران

چکیده

سفتریاکسون به‌صورت گسترده در درمان بیماری‌های عفونی استفاده میشود. عدم تصفیه‌پذیری این آنتی‌بیوتیک در تصفیه‌خانه‌های فاضلاب بیمارستانی امکان ورود آن به محیط‌های آبی و خطر مقاوم‌سازی میکربی را در این محیط‌ها افزایش می‌دهد. هدف از این پژوهش بررسی کارایی فرایند ازن‌زنی کاتالیزوری با نانوذرات اکسید منیزیم در حذف سفتریاکسون از محیط‌های آبی بود.اثر متغیرهای pH، دز ازن، زمان واکنش، دز کاتالیست و غلظت اولیه آنتی‌بیوتیک در حذف سفتریاکسون در یک راکتور آزمایشگاهی با جریان ناپیوسته مورد مطالعه قرار گرفت. غلظت باقیمانده سفتریاکسون توسط دستگاه اسپکتروفتومتری تعیین شد. آزمایش‌ها بر اساس روش یک آزمایش در زمان انجام گرفت. راندمان بهینه حذف این آنتی‌بیوتیک و شرایط  مطلوب آن مشخص شد. بهترین شرایط این راکتور در pH برابر 11، دز کاتالیست1 گرم در لیتر، غلظت آلاینده 10میلی‌گرم در لیتر، دز ازن 384/18میلی‌گرم در دقیقه و زمان واکنش 30 دقیقه راندمان 86 درصد در حذف سفتریاکسون را نشان داد. استفاده از نانوذرات اکسید منیزیم در فرایند ازن‌زنی به‌علت افزایش زمان ماند ازن در محلول آبی باعث افزایش حذف آنتی‌بیوتیک مورد نظر شد. این امر باعث کاهش هزینه‌های تصفیه به سبب کاهش ازن مصرفی در مقیاس صنعتی می‌شود.

کلیدواژه‌ها

موضوعات


عنوان مقاله [English]

Efficiency of Catalytic Ozonation by MgO Nanoparticles to Remove Ceftriaxone from Aqueous Solution

نویسندگان [English]

  • Hossein Arabzade 1
  • Mehdi Farzadkiya 2
  • ali esrafily 3
  • Majid Kermani 4
  • Yousef dadban shahamat 5
1 MSc Student of Environmental Health Engineering, School of Health, Iran University of Medical Sciences, Tehran, Iran
2 Prof. of Environmental Health Engineering, School of Health, Iran University of Medical Sciences, Tehran, Iran
3 Assist. Prof. of Environmental Health Engineering, School of Health, Iran University of Medical Sciences, Tehran, Iran
4 Assoc. Prof. of Environmental Health Engineering, School of Health, Iran University of Medical Sciences, Tehran, Iran
5 Assist. Prof. of Environmental Health Engineering, School of Health, Gorgan University of Medical Scineces, Gorgan, Iran
چکیده [English]

Ceftriaxone is widely used for healing the infectious diseases. Not being treated in hospital wastewater treatment systems, this antibiotic has the possibility of entering into the aqueous environmental and the danger of microbial resistance in these environments also increases. This study aims to examine the efficiency of catalytic ozonation process by using magnesium oxide nanoparticles to remove ceftriaxone from aqueous solutions. In this study, the effect of pH, ozone dose, reaction time, catalyst dose and initial antibiotic concentration for ceftriaxone removal were studied using a cylindrical-shaped experimental reactor through semi-batch method. The residual concentration of ceftriaxone was determined by spectrophotometer. The experiment was carried out based on the one factor at a time method and finally the optimum efficiency of ceftriaxone removal and its desired conditions were determined. The best condition of the reactor obtained in pH 11, the catalyst dose of 1g/l, ozone dose of 18.384mg/min, pollution concentration of 10mg/l and reaction time of 30 min which showed 86% of ceftriaxone removal. Due to an increase in ozone retention time, the use of magnesium oxide nanoparticles in ozonation process also increased the antibiotic removal. It leads to a decrease in treatment costs because of a decrease in ozone consumption in an industrial scale.

کلیدواژه‌ها [English]

  • Catalyst
  • Nanoparticles
  • Ozonation
  • Antibiotic
  • Ceftriaxone
  • Magnesium oxide
Alexy, R., Kümpel, T. & Kümmerer, K., 2004, "Assessment of degradation of 18 antibiotics in the closed bottle test", Chemosphere, 57(6), 505-512.
Arslan-Alaton, I. & Caglayan, A.E., 2005, "Ozonation of procaine penicillin G formulation effluent Part I: Process optimization and kinetics", Chemosphere, 59(1), 31-39.
Balcıoğlu, I. A. & Ötker, M., 2003, "Treatment of pharmaceutical wastewater containing antibiotics by O3 and O3/H2O2 processes", Chemosphere, 50(1), 85-95.
Beltrán, F.J., Aguinaco, A. & García-Araya, J.F., 2009, "Mechanism and kinetics of sulfamethoxazole photocatalytic ozonation in water", Water Research, 43(5), 1359-1369.
Brogden, R., Heel, R., Speight, T. & Avery, G., 1979, Cefoxitin: A review of its antibacterial activity, pharmacological properties and therapeutic use", Drugs, 17(1), 1-37.
Carbajo,  J. B., Petre,  A.L., Rosal,  R., Herrera, S., Letón, P., García-Calvo, E., et al., 2015, "Continuous ozonation treatment of ofloxacin: Transformation products, water matrix effect and aquatic toxicity", Journal of Hazardous Materials, 292, 34-43.
Daughton, C., 2008, "Pharmaceuticals as environmental pollutants: The ramifications for human exposure", International Encyclopedia of Public Health, 5, 66-102.
de Souza, S. M. L., de Vasconcelos, E.C., Dziedzic, M., de Oliveira, C. M. R., 2009, "Environmental risk assessment of antibiotics: An intensive care unit analysis", Chemosphere, 77(7), 962-967.
De Witte, B., Dewulf, J., Demeestere, K. & Van Langenhove, H., 2009, "Ozonation and advanced oxidation by the peroxone process of ciprofloxacin in water", Journal of Hazardous Materials, 161(2), 701-718.
Eaton, A. & Franson, M., 2005, Standard methods for the examination of water & wastewater, 21st Ed., APHA, AWWA, WEF, USA.
Fathinia, M. & Khataee, A., 2015, "Photocatalytic ozonation of phenazopyridine using TiO2 nanoparticles coated on ceramic plates: Mechanistic studies, degradation intermediates and ecotoxicological assessments", Applied Catalysis A: General, 491, 136-154.
Fick, J., Lindberg, R.H., Tysklind, M. & Larsson, D.J., 2010. "Predicted critical environmental concentrations for 500 pharmaceuticals" Regulatory Toxicology and Pharmacology, 58(3), 516-523.
Homem, V. & Santos, L., 2011, "Degradation and removal methods of antibiotics from aqueous matrices–a review", Journal of Environmental Management, 92(10), 2304-2347.
Kermani, M., Bahrami Asl, F., Faradkai, M., Esrafili, A., Salahshur Arian, S., Arfaeinia, H., et al., 2013, "Degradation efficiency and kinetic study of metronidazole by catalytic ozon ationprocess in presence of MgO nanoparticles", The Journal of Urmia University of Medical Sciences, 24(10), 839-850.
Kermani, M., Bahrami Asl, F., Farzadkia, M., Esrafili, A., Salahshour Arian, S., Khazaei, M., et al., 2015, "Heterogeneous catalytic ozonation by Nano-MgO is better than sole ozonation for metronidazole degradation, toxicity reduction, and biodegradability improvement", Desalination and Water Treatment, 2015, 1-10.
Kümmerer, K. & Henninger, A., 2003, " Promoting resistance by the emission of antibiotics from hospitals and households into effluent", Clinical Microbiology and Infection, 9(12), 1203-1214.
Lopez-Ramon, M., Stoeckli, F., Moreno-Castilla, C. & Carrasco-Marin, F., 1999, "On the characterization of acidic and basic surface sites on carbons by various techniques", Carbon, 37(8), 1215-1221.
Michael,  I., Rizzo, L., McArdell, C., Manaia, C., Merlin, C., Schwartz, T., et al. 2013, "Urban wastewater treatment plants as hotspots for the release of antibiotics in the environment: A review", Water Research, 47(3), 957-95.
Moussavi, G. & Alizadeh, R., 2010, "The integration of ozonation catalyzed with MgO nanocrystals and the biodegradation for the removal of phenol from saline wastewater", Applied Catalysis B: Environmental, 97(1), 160-167.
Moussavi, G. & Mahmoudi, M., 2009, "Degradation and biodegradability improvement of the reactive red 198 azo dye using catalytic ozonation with MgO nanocrystals", Chemical Engineering Journal, 152(1), 1-7.
Moussavi, G. & Yazdanbakhsh, A. & Heidarizad, M., 2009, "The removal of formaldehyde from concentrated synthetic wastewater using O3/MgO/H2O2 process integrated with the biological treatment", Journal of Hazardous Materials, 171(1), 907-913.
Moussavi, G., Aghapour, A. A. & Yaghmaeian, K., 2014, "The degradation and mineralization of catechol using ozonation catalyzed with MgO/GAC composite in a fluidized bed reactor", Chemical Engineering Journal, 249, 302-310.
Nagappa, B. & Chandrappa, G., 2007, "Mesoporous nanocrystalline magnesium oxide for environmental remediation", Microporous and Mesoporous Materials, 106(1), 212-218.
Ozcengiz, G.  & Demain,  A.L.,  2013, "Recent advances in the biosynthesis of penicillins, cephalosporins and clavams and its regulation", Biotechnology Advances, 31(2), 287-311.
Pourakbar, M., Moussavi, G. & Shekoohiyan, S., 2016, "Homogenous VUV advanced oxidation process for enhanced degradation and mineralization of antibiotics in contaminated water", Ecotoxicology and Environmental Safety, 125, 72-77.
Rind, F., Laghari, M., Memon, A., Mughal, U., Almani, F., Memon, N., et al., 2008, "Spectrophotometric determination of ceftriaxone using 4-dimethylaminobenzaldehyde", Pakistan Journal of Analytical & Environmental Chemistry,  9(1), 43-48.
Shams Khoramabadi, G. & Godini , H., 2014, "The efficiency of advanced oxidation process UV/H2O2  in remove the antibiotic ceftriaxone in the aquatic environment", Lorestan University of Medical Sciences Journal, 16(1), 59. (In Persian)
Sun, H., Wang, H., Ge, X. & Quin, X., 2011, "Simultaneous determination of the combined drugs ribavarin and ceftriaxone sodium in human urine by HPLC-DAD", International Journal of Science Innovations and Discoveries, 1(2), 216-225.
Tezgel, T., Babuna, F.G., Arslan-Alaton I., Iskender, G. & Okay, O., 2010, "Pretreatment of ceftriaxone formulation effluents: Drawbacks and benefits", Survival and Sustainability, P. 943-53.
Tsugura, H., Watanabe, T., Shimazaki, H. & Sameshima, S., 1998, "Development of a monitor to simultaneously measure dissolved ozone and organic matter in ozonated water", Water Science and Technology, 37(12), 285-292.
Yang, Y., Cao, H., Peng, P. & Bo, H., 2014, "Degradation and transformation of atrazine under catalyzed ozonation process with TiO2 as catalyst", Journal of Hazardous Materials, 279, 444-451.
Zhang, C., Wang, J. & Wang, Y., 2005, "Solubility of ceftriaxone disodium in acetone, methanol, ethanol, N, N-dimethylformamide, and formamide between 278 and 318 K", Journal of Chemical & Engineering Data, 50(5), 1757-1760.
Zuccato, E., Calamari, D., Natangelo, M. & Fanelli, R., 2000,  "Presence of therapeutic drugs in the environment", The Lance, 355 (9217), 1789-90.